Rare prostate cancer histologies: detection, characteristics and treatment
Nature Reviews Urology,
Take-home: Rare prostate cancer histologies comprise less than 5% of cases but represent a clinically important and under-recognized group.
These subtypes often show aggressive behaviour, atypical metastatic patterns and poorer outcomes, while remaining underrepresented in guidelines and trials.
Accurate diagnosis increasingly depends on multiparametric MRI, immunohistochemistry and genomic profiling.
Molecular alterations such as DNA repair defects, TP53/RB1 loss and mismatch repair deficiency may offer therapeutic opportunities, highlighting the need for subtype-specific evidence and prospective studies.
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