Evolution and heterogeneity of lethal metastatic bladder cancer subtypes
Take-home: A rapid-autopsy study of metastatic #BladderCancer reveals that metastasis-to-metastasis seeding is a dominant mechanism of disease spread, with greater polyclonal migration predicting poorer outcomes. Evolutionary patterns, genomic alterations, immune states, and transcriptional heterogeneity differed substantially across histological subtypes. Plasmacytoid and neuroendocrine tumors showed early aggressive drivers, while plasmacytoid tumors uniquely leveraged Fanconi anaemia pathways. Post-mortem cell-free DNA may enable non-invasive characterization of tumor heterogeneity and aggressiveness.
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Evolution and heterogeneity of lethal metastatic bladder cancer subtypes
Pushpa Itagi, Samantha L. Schuster, Sonali Arora, Thomas W. Persse, Jennifer A. Waters, Michael Yang, Alan Min, Pooja Chandra, Mohamed Adil, Patricia C. Galipeau, Dmytro Rudoy, Allie S. Kreitman, Yixin Lin, Minjeong Ko, Erolcan Sayar, Robert D. Patton, Lori Kollath, Abby Meis, Samuel Lindergren, Nathan Ji, Khursheed Ali, Hrishi Venkatesh, Cynthia L. Wladyka, A. Patrick McDeed, Claire B. Mills, Manasvita Vashisth, Jin Yeong Kim, Rosa Nadal, Jessica E. Hawley, Todd A. Yezefski, Sarah P. Psutka, John L. Gore, Daniel W. Lin, Peter S. Nelson, Heather H. Cheng, Michael T. Schweizer, Lawrence Fong, John K. Lee, Evan Y. Yu, Eva Corey, Colm Morrissey, Petros Grivas, Robert B. Montgomery, Jonathan L. Wright, Michael C. Haffner, Funda Vakar-Lopez, Omar Y. Mian, Hung-Ming Lam, Andrew C. Hsieh & Gavin Ha. Nature
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- Genitourinary
