Cribiform and intraductal carcinoma in prostate cancer-implications for risk stratification and therapeutic decision making (REVIEW)
Take-home: Intraductal carcinoma of the prostate (IDC) and invasive cribriform carcinoma are aggressive histological patterns associated with adverse pathology, metastasis, and prostate cancer mortality. Frequently underdetected on biopsy, they exhibit PTEN loss, genomic instability, DNA-repair alterations, and immunologically cold tumour microenvironments. Although these features suggest potential biomarker-directed therapies, evidence remains insufficient. Standardized reporting, improved detection, and prospective studies are essential to guide risk stratification and treatment decisions. #ProstateCancer
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Cribriform and intraductal carcinoma in prostate cancer — implications for risk stratification and therapeutic decision-making
Rui M. Bernardino, João Lobo, Zeyad Schwen, Theodorus van der Kwast, Adam B. Weiner, Robert E. Reiter, Jane K. Nguyen, Estevão Lima, Robert Stein, Nicolas Soputro, Rashed Ghandour, Alp Tuna Beksac, Karim Daher, Ricardo Leão, Mark L. Gonzalgo, Roderick van den Bergh, Juan Garisto, Giancarlo Marra, Jennifer Le Guévelou Kammerer, Sara M. Falzarano, Cristina Magi-Galuzzi, Cosimo De Nunzio, Susan Prendeville, Neil Fleshner, Jihad Kaouk & Riccardo Autorino. Nature Reviews Urology
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