Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis
Take-home: A large randomized English🇬🇧 trial involving 142,250 adults aged 50–77 evaluated annual multicancer early-detection blood testing alongside usual care. After three screening rounds, there was no significant reduction in stage III/IV cancers compared with usual care alone (incidence rate ratio 1.03; P=.63). Stage IV cancer incidence was lower with screening (IRR 0.86), although the result requires further follow-up. Trial-related adverse events were uncommon and nonserious
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Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis
Peter Sasieni, Peter Johnson, Thomas Round, Jane Warwick, Helen Jones, Saoirse Dolly, Lennard Lee, Charles Swanton. NEJM
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